DNA Repere

Deep within each cell, a fascinating universe of repair and regeneration unfolds unseen by the human eye. In our bodies' tiny laboratories, our cells wage a constant battle to maintain and repair the integrity of our DNA, the essence of our genetic instructions. Confronted with the difficulties posed by our surroundings and the contemporary way of life, our DNA is often damaged and changed. But each of us carries the power to engage our cells in the DNA repair process. It is an inner journey that begins with awareness and acceptance of the importance of cellular health. In this journey, we guide our steps towards conscious life choices. We feed our bodies nutrient- and antioxidant-rich foods that fuel cellular repair mechanisms. We get moving, stimulating blood circulation and activating detoxification and cell regeneration processes. We connect with ourselves, find ways to manage stress, and care for our mind and soul. Every step on this journey engages our cells to keep our DNA healthy and functional. It is a journey of renewal and regeneration, connecting us with the essence of our lives and reminding us that the power to take care of ourselves is always in our hands.

4/24/20242 min read

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Episode 1: How Nucleotide Excision Repair (NER) Works

Welcome to the first episode of our series on DNA and its fascinating repair mechanisms. Today, we will explore one of these essential mechanisms in detail: Nucleotide Excision Repair, or NER. This vital process maintains the integrity of our DNA, protecting us from mutations that could lead to serious diseases such as cancer. We will trace the exact steps of this process to understand how our cells maintain genetic stability in the face of damage.

Introduction to DNA and the Importance of Repair

DNA, or deoxyribonucleic acid, is the molecule that contains the genetic instructions used in the development and functioning of all living organisms and many viruses. Its structure is that of a double helix, formed by two chains of nucleotides. Each nucleotide contains a nitrogenous base, sugar and a phosphate group. Damage to this structure can have serious consequences, which is why DNA repair mechanisms are crucial.

What Is Nucleotide Excision Repair (NER)?

NER is a complex DNA repair mechanism that addresses a variety of structural lesions that distort the DNA helix, such as those produced by UV radiation or harmful chemicals. These lesions can block vital cell processes such as DNA replication and transcription.

Stages of the NER Process

Lesion Detection: It all starts when specific sensory proteins scan the DNA and detect an abnormality. These proteins are highly efficient in recognizing distortions in the double helix structure.

Recruitment and Assembly of the Repair Complex: Upon detection of damage, the cell mobilizes a complex of repair proteins to the damaged site. This complex includes, among other things, enzymes that will "cut out" the damaged section of DNA.

Nucleotide Excision: A specialized enzyme, a nuclease, cleaves the phosphodiester bonds at both ends of the damaged section, removing a segment of nucleotides.

DNA synthesis: DNA polymerase, another enzyme, adds new nucleotides using the undamaged complementary strand as a template. This step ensures that the reconstructed DNA sequence is correct and fully functional.

Final Ligation: The final step is performed by DNA ligase, which "seals" the new DNA segment to the rest of the molecule, thus restoring the structural integrity of the double helix.


Nucleotide Excision Repair is essential for preventing the accumulation of genetic errors and protecting against disease development. Through this mechanism, our cells can maintain their stability and functionality even under genetic stress. In future episodes, we'll explore other DNA repair mechanisms and their impact on our health.

This was episode one about NER, one of the most important guardians of our genetic integrity. Stay tuned for more fascinating insights from the world of molecular biology!